nonsteroidal antiinflammatory analgesic

(NSAIA) lihat di ba­wah drug.

nonsteroidal antiinflammatory analgesic (Wikipedia)
Nonsteroidal anti-inflammatory drug
Drug class
200mg ibuprofen tablets.jpg
Coated 200 mg tablets of generic ibuprofen, a common NSAID
Class identifiers
Pronunciation /ˈɛnsɛd/ EN-sed
Synonyms nonsteroidal anti-inflammatory agents/analgesics (NSAIAs), nonsteroidal anti-inflammatory medicines (NSAIMs)
Use Pain and fever
ATC code M01A
Mechanism of action Enzyme inhibitor
Biological target COX-1 and COX-2
In Wikidata

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects.

The term nonsteroidal distinguishes these drugs from steroids, which, among a broad range of other effects, have a similar eicosanoid-depressing, anti-inflammatory action. First used in 1960, the term served to distance new drugs from steroid-related iatrogenic tragedies.

The most prominent members of this group of drugs are aspirin, ibuprofen and naproxen, all available over the counter in most countries.Paracetamol (acetaminophen) is generally not considered an NSAID because it has only little anti-inflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body.

Most NSAIDs inhibit the activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), and thereby the synthesis of prostaglandins and thromboxanes. It is thought that inhibiting COX-2 leads to the anti-inflammatory, analgesic and antipyretic effects and that those NSAIDs also inhibiting COX-1, particularly aspirin, may cause gastrointestinal bleeding and ulcers.