Enterokinase

Suatu enzim yang dihasilkan oleh kelenjar-kelenjar dalam dinding usus kecil. Enzim ini mengaktifkan tripsinogen.

Merriam-Webster Online Dictionary
enterokinase (noun)
an enzyme especially of the duodenal mucosa that activates trypsinogen by converting it to trypsin
Enterokinase (Wikipedia)
enteropeptidase
1EKB.png
Crystal structure of Enteropeptidase with an inhibitor
Identifiers
EC number 3.4.21.9
CAS number 9014-74-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
protease, serine, 7 (enteropeptidase)
Identifiers
Symbol PRSS7
Entrez 5651
HUGO 9490
OMIM 606635
RefSeq NM_002772
UniProt P98073
Other data
Locus Chr. 21 q21

Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and involved in human and animal digestion. It is secreted from intestinal glands (the crypts of Lieberkühn) following the entry of ingested food passing from the stomach. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of pancreatic digestive enzymes. Absence of enteropeptidase results in intestinal digestion impairment.

Enteropeptidase is a serine protease (EC 3.4.21.9) consisting of a disulfide-linked heavy-chain of 82-140 kDa that anchors enterokinase in the intestinal brush border membrane and a light-chain of 35–62 kDa that contains the catalytic subunit. Enteropeptidase is a part of the chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.