Anafranil

merek dagang untuk preparat clomipramine hydrochloride.

Anafranil (Wikipedia)
Not to be confused with Chloripramine.
Clomipramine
Skeletal formula of clomipramine
Ball-and-stick model of the clomipramine molecule
Clinical data
Trade names Anafranil, Clofranil
AHFS/Drugs.com Monograph
MedlinePlus a697002
License data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration
Oral, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 50%
Protein binding 97-98%
Metabolism Hepatic (CYP2D6-mediated)
Biological half-life 32 hr (69 hr for active metabolite)
Excretion Renal (60%), faeces (32%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.005.587
Chemical and physical data
Formula C19H23ClN2
Molar mass 314.9 g/mol
3D model (Jmol)
  (verify)

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). It is used for the treatment of obsessive compulsive disorder, panic disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is taken by mouth.

Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Serious side effects include an increased risk of suicidal behavior in those under the age of 25, seizures, mania, and liver problems. If stopped suddenly a withdrawal syndrome may occur with headaches, sweating, and dizziness. It is unclear if it is safe for use in pregnancy. Its mechanism of action is not entirely clear but is believed to involve increased levels of serotonin.

Clomipramine was discovered in 1964 by the Swiss drug manufacturer Ciba-Geigy. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale price in the developing world is between 0.11 and 0.21 per day as of 2014. In the United States a typical dose costs about 1.20 USD per day. It was made from imipramine.