Amyloid A

AA Amyloidprotein fibriller patologis dengan berat molekul rendah yang dibentuk akibat pemecahan protein serum amyloid A (SAA). Diendapkan di dalam jaringan akibat kondisi inflamasi kronis, lihat secondary amyloidosis, di bawah amyloidosis.

Amyloid A (Wikipedia)
Human Serum amyloid A1
Symbol SAA1
Entrez 6288
HUGO 10513
OMIM 104750
RefSeq NM_199161
UniProt P0DJI8
Other data
Locus Chr. 11 p15.1
Human Serum amyloid A2
Symbol SAA2
Entrez 6289
HUGO 10514
OMIM 104751
RefSeq NM_030754
UniProt P02735
Other data
Locus Chr. 11 p15.1-p14
Human Serum amyloid A3, pseudogene
Symbol SAA3P
Alt. symbols SAA3
Entrez 6290
HUGO 10515
UniProt P22614
Other data
Locus Chr. 11 p15.1-p14
Human Serum amyloid A4
Symbol SAA4
Alt. symbols C-SAA
Entrez 6291
HUGO 10516
OMIM 104752
RefSeq NM_006512
UniProt P35542
Other data
Locus Chr. 11 p15.1-p14

Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs). These proteins are produced predominantly by the liver. The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals.