amylin

suatu polipeptida yang terdiri dari 37 asam amino dengan lebih dari 40 persen homologi dengan peptida terkait-gen calsitonin, terdapat bersama dengan insulin dalam granula sekretorik sel beta pada insulae pancreaticae yang normal; juga merupakan komponen utama dari islet amyloid pada pasien diabetes tipe 2. Amilin menghambat sintesis glikogen yang dirangsang oleh insulin di dalam otot rangka dan menghambat penggunaan glukosa yang diinduksi insulin in vivo. Disebut juga islet amyloid polypeptide.

amylin (Wikipedia)
This article is about the polypeptide. For the biotechnology company, see Amylin Pharmaceuticals.
IAPP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IAPP, DAP, IAP, islet amyloid polypeptide
External IDs OMIM: 147940 MGI: 96382 HomoloGene: 36024 GeneCards: IAPP
RNA expression pattern
PBB GE IAPP 207062 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000415
NM_001329201

NM_010491

RefSeq (protein)

NP_000406
NP_001316130

NP_034621.1
NP_034621

Location (UCSC) Chr 12: 21.35 – 21.38 Mb Chr 6: 142.3 – 142.3 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse
Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows

Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.

IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.