Antibiotika aminoglikosida semisintetis yang berasal dari kanamisin, digunakan sebagai basa atau sebagai garam sulfat pada pengobatan infeksi yang luas yang disebabkan oleh basil aerobik gram negatif dan beberapa bakteri gram positif.

Amikacin (Wikipedia)
Amikacin ball-and-stick.png
Clinical data
Trade names Amikin, others
AHFS/ Monograph
MedlinePlus a682661
  • AU: D
  • US: D (Evidence of risk)
Routes of
intramuscular, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding 0-11%
Biological half-life 2-3 hours
Excretion kidney
CAS Number
PubChem CID
ECHA InfoCard 100.048.653
Chemical and physical data
Formula C22H43N5O13
Molar mass 585.603 g/mol
3D model (Jmol)

Amikacin is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle.

Common side effects include hearing loss, balance problems, and kidney problems. Other side effects include paralysis resulting in the inability to breathe. If used during pregnancy it may cause permanent deafness in the baby. Amikacin is in the aminoglycoside family of medications. It works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to make protein.

Amikacin was patented in 1971 and came into commercial use in 1976. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 13.80 to 130.50 USD for a month. In the United States a typical course of treatment costs 25 to 50 USD. It is made from kanamycin.