Antibiotika aminoglikosida semisintetis yang berasal dari kanamisin, digunakan sebagai basa atau sebagai garam sulfat pada pengobatan infeksi yang luas yang disebabkan oleh basil aerobik gram negatif dan beberapa bakteri gram positif.
|Trade names||Amikin, others|
|Biological half-life||2-3 hours|
|Chemical and physical data|
|Molar mass||585.603 g/mol|
|3D model (Jmol)|
Amikacin is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle.
Common side effects include hearing loss, balance problems, and kidney problems. Other side effects include paralysis resulting in the inability to breathe. If used during pregnancy it may cause permanent deafness in the baby. Amikacin is in the aminoglycoside family of medications. It works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to make protein.
Amikacin was patented in 1971 and came into commercial use in 1976. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 13.80 to 130.50 USD for a month. In the United States a typical course of treatment costs 25 to 50 USD. It is made from kanamycin.