Aldactone

Merek dagang untuk preparat spironolakton.

Aldactone (Wikipedia)
Not to be confused with spirolactone.
Spironolactone
Skeletal formula of spironolactone
Ball-and-stick model of the spironolactone molecule
Clinical data
Pronunciation spy-ROW-no-LAK-tone or speer-OH-no-LAK-tone
Trade names Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others
AHFS/Drugs.com Monograph
MedlinePlus a682627
Pregnancy
category
  • AU: B3
  • US: C (Risk not ruled out)
Routes of
administration
By mouth,topical
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80–90%
Protein binding Spironolactone: 88% (to albumin and AGP equivalently)
Canrenone: 99.2% (to albumin)
Metabolism Liver (deacetylation, dethiolation, and thiomethylation)
Metabolites 7α-TMS, 6β-OH-7α-TMS, canrenone, others
(All three active)
Biological half-life Spironolactone: 1.4 hours
7α-TMS: 13.8 hours
6β-OH-7α-TMS: 15.0 hours
Canrenone: 16.5 hours
Excretion Urine, bile
Identifiers
Synonyms SC-9420; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.000.122
Chemical and physical data
Formula C24H32O4S
Molar mass 416.574 g/mol
3D model (Jmol)
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Spironolactone, marketed under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early-onset puberty, and acne and excessive hair growth in women. It is also used for hormone therapy in transgender women. Spironolactone is taken by mouth.

Common side effects include electrolyte abnormalities, particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. In those with liver or kidney problems, extra care should be taken. Spironolactone has not been well studied in pregnancy and should not be used to treat high blood pressure of pregnancy. It is a steroid that blocks the effects of the hormones aldosterone and testosterone and has some effects similar to those of the hormone progesterone. Spironolactone belongs to a class of medications known as potassium-sparing diuretics.

Spironolactone was introduced in 1959. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world as of 2014 is between 0.02 and 0.12 USD per day. In the United States it costs about 0.50 USD per day.