Malformasi karena konvulsi korteks serebri tidak berkembang normal dan otak biasanya kecil.

Agyria (Wikipedia)
"Agyria" redirects here. It is not to be confused with Argyria.
Lissencephalic brain of human. Lacking surface convolutions (Gyrification).
Classification and external resources
Specialty medical genetics
ICD-10 Q04.3
ICD-9-CM 742.2
OMIM 607432 601545 247200 300121 236670 253800 253280 257320 611603 300215
DiseasesDB 29492
MeSH D054082
Orphanet 48471
MRI scan showing the characteristic smooth brain of an individual with lissencephaly

Lissencephaly is a set of rare brain disorders where the whole or parts of the surface of the brain appear smooth. The word lissencephaly is derived from the Greek λισσός lissos meaning "smooth" and encephalos meaning "brain". It is caused by defective neuronal migration during the 12th to 24th weeks of gestation resulting in a lack of development of brain folds (gyri) and grooves (sulci). It is a form of cephalic disorder. Terms such as agyria (no gyri) and pachygyria (broad gyri) are used to describe the appearance of the surface of the brain. Children with lissencephaly generally have significant developmental delays, but these vary greatly from child to child depending on the degree of brain malformation and seizure control. Life expectancy can be shortened, generally due to respiratory problems.